In a concerted effort to reduce health disparities and improve access to care for colorectal cancer screenings in Chicago, Sinai Chicago Health System (Sinai), Chicago Family Health Center, and Lawndale Christian Health Center have joined forces as part of the Collaboration for Equitable Health (CFEH). Powered by Bank of America and led by the American Heart Association®, the American Cancer Society®, and the American Diabetes Association®, CFEH aims to address systemic health inequities, particularly focusing on the South and West Side communities in Chicago. The four-year, $25-million collaboration, launched in 2022, aims to improve health outcomes for Black, Hispanic/Latino, Asian American and Native American communities, with a specific focus on the leading causes of death in communities of color: heart disease, cancer, stroke, and diabetes. Chicago is one of 11 cities where the CFEH was initially launched.  Health inequities for Black, Hispanic-Latino, Asian American, and Native American populations represent a longstanding systemic challenge that was exacerbated by the pandemic. In these underrepresented communities, heart disease, cancer, unintentional injury, stroke, and diabetes are the top five leading causes of death. The collaboration between these esteemed health organizations signifies a significant step forward in addressing health disparities and promoting equitable access to healthcare resources for all Chicagoans.